Covid Articles and Links
Cardiac
COVID-19 surges linked to spike in heart attacks
BREAKING! Early Data Shows That New SARS-Cov-2 Sub-lineages BQ.1.1 And BM.1.1 Attacks The Endothelial Cells Of The Gut Ferociously And Causes Disease Severity - Thailand Medical News
COVID and the Heart: It Spares No One | Johns Hopkins | Bloomberg School of Public Health
Study: Myocarditis risk 2 to 3 times higher from Moderna than Pfizer COVID-19 vaccine - UPI.com
Strokes, heart attacks, sudden death: Does America understand the long-term risks of catching COVID? | Fortune
Heart risks fuel debate over COVID-19 boosters
Heart-disease risk soars after COVID — even with a mild case
Vaccines
Pfizer seeks authorization for new Covid booster, without fresh clinical data
Efficacy of the mRNA-1273 SARS-CoV-2 Vaccine at Completion of Blinded Phase | NEJM
Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants | NEJM
FDA’s vaccines chief sees possibility of more Covid boosters
Novavax
Novavax Submits Application to the U.S. FDA for Emergency Use Authorization for Novavax COVID-19 Vaccine, Adjuvanted as a Booster in Adults Aged 18 and Older - Aug 15, 2022
Covid-19: Whatever happened to the Novavax vaccine? | The BMJ
Covid - Two large phase-3 trials of Novavax's Covid-19 vaccine show high levels of protection against infection: Research head - Telegraph India
Novavax Prototype COVID-19 Vaccine Data Support Homologous and Heterologous Boosting and Suggest Benefit Against Variants - Oct 12, 2022
Efficacy and Safety of NVX-CoV2373 in Adults in the United States and Mexico | NEJM
Search of: Novavax - List Results - ClinicalTrials.gov
Novavax Phase 3 COVID-19 Omicron Trial Supports the Continued and Future Use of Novavax Prototype Vaccine as a Booster - Nov 8, 2022
Epidemiology
Original Antigenic Sin: How Original? How Sinful?
An Outbreak of SARS-CoV-2 Omicron Subvariant BA.2.76 in an Outdoor Park — Chongqing Municipality, China, August 2022
Immunity Debt
5 big reasons why kids are getting sick and flooding ERs — and 'immunity debt' isn't one of them
"Immunity Debt" - by Anthony J Leonardi, PhD - Easy Chair
Colin Furness MISt PhD MPH MEd(cand) on Twitter: "A word on the idiocy known as "immunity debt". How did such a nonsensical idea take hold? Simple. The obvious mental model for our immune system is a muscle: use it or lose it. Muscles atrophy when we don't use them. The same mental model works for our memories & skills. 1/19" / Twitter
Quantifying the RSV immunity debt following COVID-19: a public health matter - The Lancet Infectious Diseases
‘Immunity debt’ is a misguided and dangerous concept
Prevention
Hydrogen peroxide kills 99.99% of SARS-CoV-2 on fabrics in 30 seconds
Masks
Psychologists: Masks do not impede preschoolers’ language development
Long COVID
Alzheimer’s Disease Risk 50–80% Higher in Older Adults Who Caught COVID-19
'Long Covid is going to push us to get outside of our comfort zone' - STAT
Scientists hail autoimmune disease therapy breakthrough | Science | The Guardian
Immune Disfunction
NVX-CoV2373 vaccination induces functional SARS-CoV-2–specific CD4+ and CD8+ T cell responses | bioRxiv
T cell apoptosis characterizes severe Covid-19 disease | Cell Death & Differentiation
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection
General
Stop Telling Americans That They’re “Tired of Covid” | The Nation
A new strain of avian flu is decimating wild birds. Humans should worry | Financial Times
Operation Nasal Vaccine—Lightning speed to counter COVID-19 | Science Immunology
(2) T. Ryan Gregory on Twitter: "Preventing panic (and action) during a pandemic: a guide for minimizers 🧵" / Twitter
Patrick Hickey, MD on Twitter: "My thoughts on updated CDC guidelines for COVID, section by section: https://t.co/oAlx3cgvjU" / Twitter
High-Contact Object and Surface Contamination in a Household of Persons with Monkeypox Virus Infection — Utah, June 2022 | MMWR
New Covid variant can reinfect you every MONTH and it's outpacing other strains - Mirror Online
Google Covid Outbreak Now Largest Of Any Employer In Los Angeles – Deadline
26 states reporting BA.2.75 cases
Incubation Period of COVID-19 Caused by Unique SARS-CoV-2 Strains: A Systematic Review and Meta-analysis | Infectious Diseases | JAMA Network Open | JAMA Network
What were the historical reasons for the resistance to recognizing airborne transmission during the COVID‐19 pandemic? - Jimenez - 2022 - Indoor Air - Wiley Online Library
SARS-CoV-2 infects multiple species of North American deer mice and causes clinical disease in the California mouse | bioRxiv
COVID rebound is surprisingly common — even without Paxlovid
The role of IgA in COVID-19 - PMC
The features of the newly emerging SARS-CoV-2 Omicron BA.2.75 subvariant
The T cell immune response against SARS-CoV-2 | Nature Immunology
Vipin M. Vashishtha on Twitter: "#SARS2 can readily alter its Spike protein via a single Amino acid substitution so that it is not recognized by CD8 T cells targeting the most prevalent epitope in Spike restricted by the most common HLA-I across the population. 1/" / Twitter
Immunization with SARS-CoV-2 Nucleocapsid protein triggers a pulmonary immune response in rats | PLOS ONE
What are antibodies? | Live Science
Mucosal vaccines and technology - PMC
Assessment of T-cell Reactivity to the SARS-CoV-2 Omicron Variant by Immunized Individuals | Allergy and Clinical Immunology | JAMA Network Open | JAMA Network
An introduction to immunology and immunopathology | Allergy, Asthma & Clinical Immunology | Full Text
Don Ford - #LongCOVIDisDestroyingLives #ZeroCOVID on Twitter: "@BoetticherBudd @RajlabN I misunderstood you. The current Novavax vaccine already does that. https://t.co/m2SZD0zN97" / Twitter
Endothelial activation and dysfunction in COVID-19: from basic mechanisms to potential therapeutic approaches | Signal Transduction and Targeted Therapy
Evidence showing lipotoxicity worsens outcomes in covid-19 patients and insights about the underlying mechanisms - ScienceDirect
Characterization of SARS-CoV-2 Omicron BA.2.75 clinical isolates | bioRxiv
SARS-CoV-2 Omicron BA.2.75 variant may be much more infective than preexisting variants | bioRxiv
How nasal-spray vaccines could change the pandemic
Long COVID Symposium — World Health Network
Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial. - PMC
Pre-exposure to mRNA-LNP inhibits adaptive immune responses and alters innate immune fitness in an inheritable fashion - PubMed
Imagining COVID is 'like the flu' is cutting thousands of lives short. It's time to wake up
The Lancet Commission on lessons for the future from the COVID-19 pandemic - The Lancet
Severe fatigue as symptom of long COVID is characterized by increased expression of inflammatory genes in monocytes, increased serum pro-inflammatory cytokines, and increased CD8+ T-lymphocytes. A putative dysregulation of the immune-brain axis, the coag… | medRxiv
Pandemic News on Twitter: "BA.2.75.2 evades BA.5 immunity. Let that sink in." / Twitter
Omicron sublineage BA.2.75.2 exhibits extensive escape from neutralising antibodies | bioRxiv
Imprinted SARS-CoV-2 humoral immunity induces convergent Omicron RBD evolution | bioRxiv
Long COVID patients show signs of autoimmune disease a year after infection
Mucosal plasma cells are required to protect the upper airway and brain from infection - ScienceDirect
‘I'm Dropping My COVID Hubris,’ Vows a Top Immunologist | The Tyee
Imprinted antibody responses against SARS-CoV-2 Omicron sublineages - PMC
Covid-19: Omicron infection is poor booster to immunity, study finds | The BMJ
Total formulation impacts a surface sanitizer's efficacy against norovirus, finds study
Big COVID-19 waves may be coming, new Omicron strains suggest | Science | AAAS
SARS-CoV-2 Omicron variant emerged under immune selection | Nature Microbiology
Effectiveness of mRNA-1273 against infection and COVID-19 hospitalization with SARS-CoV-2 Omicron subvariants: BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 | medRxiv
SARS-CoV-2 disrupts host epigenetic regulation via histone mimicry | Nature
Structural insights for neutralization of Omicron variants BA.1, BA.2, BA.4, and BA.5 by a broadly neutralizing SARS-CoV-2 antibody | Science Advances
Beilue: One of politics' 'most evocative' photos taken in Amarillo
How the splintering of Omicron could shape Covid's next phase - STAT
Surveillance for Adverse Events After COVID-19 mRNA Vaccination | Vaccination | JAMA | JAMA Network
The marked contrast in pandemic outcomes between Japan and the United States
Vaxart, Inc. –Vaxart Publishes Clinical Data Suggesting its Oral COVID-19 Pill Vaccine Candidate Induces Long-Lasting Mucosal Immune Responses that are Highly Cross-Reactive
T. Ryan Gregory on Twitter: "It needs to be emphasized that what we're seeing with SARS-CoV-2 variant evolution now is something new. 🧵" / Twitter
National norovirus and rotavirus bulletin week 40: data to week 38 (25 September 2022) - GOV.UK
Survey Finds More Than 40% of Americans Misled Others About Having COVID-19 and Use of Precautions | University of Utah Health
Virological characteristics of the SARS-CoV-2 Omicron BA.2.75 variant: Cell Host & Microbe
The roles of nausea and vomiting in COVID-19: did we miss something? - ScienceDirect
Vaccines alone cannot slow the evolution of SARS-CoV-2 | medRxiv
Quarantine Station Contact List, Map, and Fact Sheets | Quarantine | CDC
Denmark: A soup of 120 Covid variants sequenced in one month - Coronaheadsup.com
As Omicron mutates wildly the virus shows first signs of convergent evolution
Medium COVID Could Be the Most Dangerous COVID - The Atlantic
Bivalent mRNA vaccine booster induces robust antibody immunity against Omicron lineages BA.2, BA.2.12.1, BA.2.75 and BA.5 | Cell Discovery
Pfizer and BioNTech Announce Positive Early Data From Clinical Trial of Omicron BA.4/BA.5-Adapted Bivalent Booster in Individuals 18 Years and Older | Business Wire
Clinician Guide to Angiogenesis | Circulation
Elevated vascular transformation blood biomarkers in Long-COVID indicate angiogenesis as a key pathophysiological mechanism | Molecular Medicine | Full Text
Endothelial dysfunction in COVID-19: an overview of evidence, biomarkers, mechanisms and potential therapies | Acta Pharmacologica Sinica
COVID-19 Linked to Excessive Destruction of Connections Between Nerve Cells - Neuroscience News
Evolution of immune genes is associated with the Black Death | Nature
Can long Covid lead to death? A new analysis suggests it could - POLITICO
Which Animals Catch COVID? This Database Has Dozens of Species and Counting - Scientific American
Reckoning With The Dead: Reporter Goes Inside COVID-19 Morgue : Shots - Health News : NPR
Antibody responses to Omicron BA.4/BA.5 bivalent mRNA vaccine booster shot | bioRxiv
The ACE-2 receptor accelerates but is not biochemically required for SARS-CoV-2 membrane fusion. | bioRxiv
Immune system-evading hybrid virus observed for first time | Infectious diseases | The Guardian
Unadjuvanted intranasal spike vaccine elicits protective mucosal immunity against sarbecoviruses | Science
Is SARS-CoV-2 an oncogenic virus? - Journal of Infection
What We Know: New COVID Variants BQ.1, BQ.1.1, XBB, BF.7
How to eradicate the next pandemic disease
Jonathan Reiner on Twitter: "Japan has an older population about 40% the size of the US but has had only 47,000 COVID deaths (4% the US total). Explain to me (like I’m just a simple cardiologist) why this is so." / Twitter
Traditional Japanese food may hold building b | EurekAlert!
Decreased Influenza Activity During the COVID-19 Pandemic — United States, Australia, Chile, and South Africa, 2020 | MMWR
Cleaning up the hygiene hypothesis | PNAS
Covid-19 is a leading cause of death in children and young people ages 0-19 years in the United States | medRxiv
Waning immunity against respiratory syncytial virus during the COVID-19 pandemic - PMC
Immunological dysfunction persists for 8 months following initial mild-to-moderate SARS-CoV-2 infection | Nature Immunology
India-Made Drug Shown To Treat Heart Damage Caused By Covid Protein: Study
What If COVID Reinfections Wear Down Our Immunity? | The Tyee
Viral load dynamics of SARS-CoV-2 Delta and Omicron variants following multiple vaccine doses and previous infection | Nature Communications
Adapt or die: how the pandemic made the shift from EBM to EBM+ more urgent | BMJ Evidence-Based Medicine
How to think like an aerosol scientist this holiday season to stay healthy | Colorado Public Radio
Bacterial chemotaxis in human diseases: Trends in Microbiology
Scientists Make Breakthrough in Developing a New Vaccine That Could Finally Beat COVID
Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis | BMC Medicine | Full Text
Self-Reported Long COVID and Its Association with the Presence of SARS-CoV-2 Antibodies in a Danish Cohort up to 12 Months after Infection | Microbiology Spectrum
Hospitals hitting capacity from RSV, flu, covid and staffing shortages - The Washington Post
Immunogenicity and safety of a 4th homologous booster dose of a SARS-CoV-2 recombinant spike protein vaccine (NVX-CoV2373): a phase 2, randomized, placebo-controlled trial | medRxiv